Chemical pesticides, widely used since the introduction of DDT, pose significant risks to human health and ecosystems. To address these concerns, there is growing interest in natural alternatives such as plant-based pesticides. This study evaluates the efficacy of aqueous extracts from Neem (Azadirachta indica) and Tulsi (Ocimum tenuiflorum) against Odontotermes obesus termites, significant pests causing economic damage to structures. Neem and Tulsi leaves collected were processed into aqueous solutions at concentrations of 0.25, 0.5, and 0.75 mg/ml. Termites were collected and housed under controlled conditions, and mortality rates were monitored over 72 hours after exposure to the extracts. Data analysis revealed concentration-dependent mortality, with Neem extract inducing 100% mortality at 48 hours (0.75 mg/ml), and Tulsi extract achieving similar results at 72 hours (0.75 mg/ml). LC50 values indicated Neem's slightly higher potency at 72 hours (0.2 mg/ml) compared to Tulsi (0.25 mg/ml). These findings underscore the potential of Neem and Tulsi extracts as effective biopesticides against termites, highlighting Neem's rapid action and potency over extended exposure periods.