Different bio-pesticides were evaluated against eggplant shoot and fruit borer, Leucinodes orbonalis G. in combination. All combination of bio-pesticides were effective against eggplant shoot and fruit borer but Lycomax + Biotin M + Antario and Lycomax + Biotin M + Fytomax 3% found most potent and control 88.43 and 84.06 percent shoot infestation; 69.67 and 66.44 percent fruit infestation by count; 72.70 and 70.49 percent fruit infestation by weight, respectively. Lycomax + Biotin M + Antario and Lycomax + Fytomax 0.1% + Biomax increased 32.90 and 28.66 percent gross yield; 120.19 and 87.5 percent marketable yield, respectively over control. Individual fruit weight found maximum from Lycomax + Fytomax 0.1% + Biomax and Biotin M + Antario where it was 51.74 g and 48.13 g for marketable fruit while 44.05 g and 44.61 g for infested fruit. The present study revealed that Lycomax + Biotin M + Antario and Lycomax + Biotin M + Fytomax 3% effectively control ESFB while Lycomax + Biotin M + Antario and Lycomax + Fytomax 0.1% + Biomax increases the yield. Therefore, application of Lycomax + Biotin M + Antario might be recommended for successful production of eggplant to get maximum yield with minimum infestation.