author(s)
Priyadharshini Pachiappan, Prabhu S, Thangamalar A and Maria Joncy A

abstract
The present study was investigated on wound healing activity of sericin in rats using excision model. The results indicated that both sericin 4% and sericin 8% improved wound healing activity than control on 7^th day and 14^th day. Wound contraction was significantly increased in wounds treated with sericin when compared to wounds treated with neosporin and untreated wounds, which indicated that sericin had shown more wound healing property than control. Also observed that there were no rashes on the skin treated with sericin when compared to control wound. Appearance of inflammation in wound areas were observed in all groups on first day of treatment. But the inflammation in sericin treated group was gradually reduced from 4th day onwards which proved that sericin is a very good biomaterial agent for wound healing. Histological analysis revealed that the tissue section of wound control showed only re epithelialization and there was no proliferation of fibroblasts and evenness of epidermis was seen in control when compared to sericin treated wounds which showed evenness of epidermis and increased number of fibroblasts.