author(s)
A Elamaran, S Ramesh, S Vairamuthu and V Ranganathan

abstract
An investigation was carried out in the heart homogenates of broilers to study the effect of enrofloxacin induced oxidative stress and its amelioration by alpha-lipoic acid (ALA) and its comparison with the conventional antioxidant vitamin E, by analyzing the effect of them on oxidative biomarkers. Treatment with either ALA (100 mg/kg b.w) or vitamin E (100 mg/kg b.w) significantly restored the antioxidant status in the enrofloxacin (10 mg/kg b.w) induced oxidative stress in heart homogenates of broilers. Whereas, treatment combined with vitamin E and ALA treated group had significantly restored the antioxidant parameters which are comparable with the normal control birds. Thus the results of this study suggest that the combination of ALA and vitamin E with enrofloxacin administration effectively restored the normal antioxidant status which was comparable to normal control than either of these drugs alone.