author(s)
Manju Roy, Sushovan Roy S, Roopali B, Ratre HK, Nishma Singh, Jasmeet Singh and Rupal Pathak

abstract
The aim of this study was to ascertain the toxic effect of sodium arsenite in rat and its amelioration by supplementation with Tamarindus indica seed coat powder (TISCP). Eighteen albino rats were randomly assigned to three groups. All animals received standard feed and water. The first group served as healthy control. The second and third group received sodium arsenite (2mg/kg b.wt) through drinking water. The third group also received TISCP (200 mg/kg body weight) daily for a period of 45 days. Biological samples were analysed for biochemical parameters and oxidative biomarkers for the determination of hepatotoxic effect in arsenic intoxication. Significant (P<0.05) increase activity of serum AST, ALT and ALP whereas decreased total protein and albumin level was recorded as a marker of hepatic damage. Decrease antioxidant status of animals was recorded with increased lipid peroxidation levels. Co-administration of TISCP during exposure to arsenic through drinking water restored serum hepatic and oxidative markers. It is concluded that TISCP has an ameliorative potential to protect the liver from arsenic induced damage.