Epilachna beetle (Henosepilachna vigintioctopunctata Fab.) is a poly-phagous pest, severely affecting brinjal. A field experiment was conducted to study the response of fifty nine genotypes which include germplasm accessions, commercial high yielding varieties as well as F1 hybrids and a wild spp. i.e. Solanum sysibrifolium against epilachna beetle which was carried out during Kharif season in the year of 2018-19. No field infestation was observed in S. sisymbrifolium being highly resistant to epilachna beetle with lowest infestation percentage and lowest number of grubs/ adults per plant. S. sisymbrifolium was the best source of resistance against epilachna beetle which was confirmed by choice test as well as no-choice test.