author(s)
B Puvarajan, T Lurthu Reetha, S Senthil Kumar and R Manickam

abstract
A retrospective study for a period from January 2017- December 2018 was conducted by analysing the clinical samples of animals affected due to various disease condition like mastitis, wounds, otitis, reproductive infections and respiratory affections in and around the Orathanadu region, Thanjavur District of Tamilnadu. The study revealed isolation of microorganisms such as mastitis (E.coli- 181 isolates), Staphylococcus spp. (149 isolates from otitis externa of canines), Klebsiella spp. (43 isolates from wounds), Pseudomonas spp –(18 isolates from reproductive tract infections) and Pasteurella spp.(13 isolates from respiratory tract infections). Owing to the abundancy of coliform mastitis cases in bovines and otitis cases in canines, the antibiotic resistance pattern of Escherichia coli for 181 samples from clinical cases of mastitis and Staphylococcus spp. from 149 samples were estimated with 16 number of antibiotics and Nalidixic acid showed a more higher resistance (92.8%) and Penicillin showed highest resistance (91.7%), Streptomycin (87.8%) and Trimethoprim-Sulfamethoxazole (78.4%) in mastitis cases caused by E.coli and Tetracycline showed highest resistance(93.28%), Trimethoprim-Sulfamethoxazole (91.9%) and Streptomycin. Hence this study would provide a judicial insight of appropriate antibiotic use and their association with antibiotic resistance in this agrarian Orathanadu region of Tamil Nadu and the multiple drug resistance will help to rationalise the antibiotics for public and field veterinary practitioners.