A male Labrador of 6 years with weight gain, lethargy, weakness, alopecia (rat tail, thin hair, truncal symmetrical), cold intolerance, neurologic signs was brought and a tentative diagnosis of hypothyroidism was done. The aim of the study was to diagnose the dogs with hypothyroidism. The blood of the dog was sent for haematological examination and T4 in the blood. The results revealed slightly lower value of T4 giving evidence of hypothyroidism. The owner was advised to bring the dog for regular visits and after 6 the visits improvement was noticed after treatment with Oral T4 (levothyroxine sodium) (0.022 mg per kg).