author(s)
SK Yadav, Raju Sharda, Shailendra Kumar Tiwari, Rukmani Dewangan, MO Kalim, MV Kamble and Anupam Soni

abstract
The study was carried out in twenty-four Wistar rats to evaluate the effect of Cissus quadrangularis on long bone fracture healing. The animals were randomly divided in to four equals groups that are Group I, II, III and IV which consisted of six animals in each group. In Group I-the rats were kept as healthy control, Group II the fractured rats were kept as operative control, Group III the fractured rats were subjected to treatment by using Cissus quadrangularis (CQ) P.O 400mg/kg body weight daily for 30 days and in Group IV-the fractured rats were subjected to treatment by using tropical application of Cissus quadrangularis (CQ) on site daily for 30 days. The, haemato-biochemical parameters were assessed. There were transient changes in hematological parameters which remained within normal physiological limits whereas, significant (p<0.05) changes observed in biochemical parameters. The animals which were given oral administration of Cissus quadrangularis in (Group III) resulted in early healing of fractured bone as compared to other groups. Topical application of Cissus quadrangularis (group IV) was done as it took slightly longer time. However, both group III and IV were better than the untreated group II (operative control) where no treatment was given. Therefore, it could be concluded that Cissus quadrangularis induces early long bone fracture healing.