author(s)
N Peetambari Devi, J Rajashekaran Nair, KV Jayachandran, Devika Pillai, Alphy Korath and Nongmaithem Raju Singh

abstract
The present investigation demonstrates the antifungal activity of accessory nidamental glands (ANGs) and nidamental glands (NGs) of Uroteuthis singhalensis against selected microbe’s viz., Aspergillus flavus, A. fumigatus, Candida albicans and Fusarium solani. The mature ripe female squid NGs and ANGs were collected and extracted by using two solvents namely ethanol and butanol. Disc diffusion technique was employed to determine the antifungal property of different extracts. The antibiotic Amphotericin-b was taken as positive control. It was found that the use of different solvent for extraction on expression of antifungal activity by different fungal strains found to be significant varied. The highest antifungal activity in ANGs extract by using ethanol (12 ±0.47 mm) and butanol (15±0.39 mm) solvents was achieved against Aspergillus fumigatus and Aspergillus flavus respectively. Similar result was also found in NGs extracts. Interestingly, the different extracts did not show any antifungal activity against the fungal strain Fusarium solani. Overall, the results showed that butanol solvent extraction had exhibited greater inhibitory effect as compared to ethanol solvent extraction.