author(s)
Dr. Srinivas Reddy Bellur, Dr. M Narayana Swamy, Dr. ShrikanthKulkarni, Dr. GP Kalmath, Dr. Sathisha KB and Dr. Swetha HS

abstract
The present study was conducted with an attempt to evaluate the influence of euthyroidism and hypothyroidism in relation to chronic kidney disease in dogs. A total number of 72 client-owned dogs aged between two to ten years, presented to the Veterinary College Hospital, Bangalore, were included in this study. Clinically healthy dogs were assigned to Group I, euthyroid dogs with chronic kidney disease were assigned to Group II and hypothyroid dogs with chronic kidney disease were assigned to Group III. The selected dogs were in the age range of 2-4 years, >4-6 years, >6-8 years and >8-10 years with six dogs in each group. The dogs of all breeds and of either sex were included in the study. A single blood sample from the study dogs was collected at the time of presentation to clinics. Serum samples obtained were utilised for assay of aminotransferases and lipid profile using standard reagent kits. Significantly higher aminotransferase activities, total cholesterol and triglycerides were recorded in Group III compared to Group I and Group II. From the study it is concluded that the renal dysfunction exerted mild effects and hypothyroidism exerted marked influence on serum enzyme and lipid profile. Hhypothyroidism, being one of the most common causes of secondary dyslipidemia resulting in fatty liver, leading to leakage of liver specific enzymes into circulation in Group III dogs.