author(s)
Rashmi R, N Prakash, HD Narayanaswamy, M Narayana Swamy, D Rathnamma, PT Ramesh, U Sunilchandra, Naveen Kumar S, KR Anjan Kumar and Vanishree H

abstract
Natural compounds have gained a promising role in both cancer prevention and therapy. They play an important role in the discovery of lead compounds and represent an excellent source of novel anticancer drugs. Curcumin is a renowned natural compound derived from the rhizome Curcuma longa L, commonly known as turmeric. In the present study, the cytotoxicity potential of curcumin on MDA-MB-231 cell lines was determined by MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assay. It was conducted at 48h incubation to determine percent cell viability. The IC₅₀ value of curcumin was 18.54μM. The curcumin showed dose-dependent cytotoxicity on triple-negative breast cancer cells. The in vitro cytotoxicity potential of curcumin in terms of percent cell viability proved to be relatively effective on triple-negative breast cancer cells.