Advancement in biomaterials for chronic wounds therapy
Dr. Anjali Gautam, Dr. Kumar Govil, Dr. Dinesh Thakur, Adesh Kumar and Dr. KPS Saini
Wound healing, as a complex biological process in the body, comprising four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successful and fast, all four phases must occur in the proper sequence and in time. Many factors like oxygenation, infection, age, stress, diabetes, etc may cause improper or impaired wound healing. A better understanding of the influence of these factors on repair may lead to therapeutics that improves wound healing. This paper reviews the latest applications in advanced dressings like skin substitutes, biologic wound products including growth factor applications, silver, platelet rich plasma, by inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate super absorber in microbial prophylaxis as an adjunct in wound healing. A number of recent advance techniques are discussed, with the aim of developing strategies to improve the rate of tissue repair in wound healing.
Dr. Anjali Gautam, Dr. Kumar Govil, Dr. Dinesh Thakur, Adesh Kumar, Dr. KPS Saini. Advancement in biomaterials for chronic wounds therapy. J Entomol Zool Stud 2019;7(6):674-679.