author(s)
Majid Shafi and Shabia Shabir

abstract
This experimental work was conducted to elucidate the in vivo evaluation of diclofenac induced sub-acute toxicity in Japanese quails. For this study, 100 apparently healthy Japanese quail’s birds of either sexes were randomly divided into control and treatment groups comprising of 50 birds in each group. The birds in treatment group were given 10 mg/kg body weight of diclofenac sodium for 10 days. The intoxicated birds revealed moderate lesions of gout characterized by deposition of white chalky urates on the organ surface. The intoxicated birds also revealed nephropathy and immunosuppression as evident by the depletion of lymphoid tissue from the lymphoid organs.