Blood transfusion is the transfusion of the whole blood or its components (blood cells or plasma) obtained from a healthy animal (donor) to another animal (recipient) whose blood is deficient in quantity and quality. In animals blood transfusion may help to restore the blood loss, recovery from anaemia, to overcome the deficiencies of plasma proteins and clotting factor. it also help to improve immunity in sick animals. Blood transfusion is the first line therapy in the treatment of animal which suffering from various type of haemorrhage or blood loss. Infect like humans animals having so many types of blood groups so before going transfusion proper record the amount of blood, type, blood group, rate of transfusion and any type of reaction. This article provides the information about general indication of blood transfusion, blood groups, donor selection, blood collection, cross matching and blood transfusion in different species like cattle, horse, dog, cat, sheep and goat.