An adult Murrah buffalo bull presented for the post-mortem examination to the department of Veterinary Pathology, College of Veterinary Science & A.H., Anjora, Durg, Chhattisgarh. Animal had the history of respiratory distress characterized by nasal discharge and laboured breathing. On external examination, the animal showed pale mucous membranes and rough hair coat. Upon necropsy peritoneum and endocardium exhibited fibrinous deposition along with congested liver and kidney. Lungs of the animal were severely congested and emphysematous, filled with numerous small sized air bubbles, making it unable to collapse. Histopathological examination revealed haemorrhage and congestion in the liver and kidneys. Microscopic changes in lungs were predominated and suggestive of emphysema characterized by enlargement of airspaces, destruction of alveolar walls and loss of alveolar unit. Pulmonary emphysema is an important pathological condition in buffaloes mostly occurs as a result of lung diseases of various causes, may lead to severe respiratory distress followed by respiratory failure and death of the animal.