author(s)
Ankit Kumar Ahuja, Mrigank Honparkhe, Guranshpreet Singh Sethi, Navgeet Singh, Fiza Jan and Pallavi Chauhan

abstract
Pyometra is one of the most common diseases in intact bitches. It is usually accompanied by glomerular and tubular dysfunction leading to renal failure. Present report depicts the involvement of multiple organ system along with pyometra leading to the systemic inflammatory response syndrome. Ovariohysterectomy was performed after stabilizing the animal however the animal died ten days after the surgery due to renal failure. Future perspective includes development of prophylactic measure like the development of a vaccine designed against certain virulent factors of bacteria associated with pyometra can be done for susceptible animals. Hence prompt diagnosis and early treatment schedule that may be parenteral therapy or surgical approach (ovariohysterectomy) would subject the older animal to good prognosis.