The present experiment was conducted to evaluate the effect of poly-herbal mixture and butyric acid supplementation, alone and in combination on postpartum reproductive disorders of Murrah buffaloes. A total 36 multiparous Murrah buffaloes were selected and randomly divided into four groups, three groups were for three different types of supplementary feeding (T1, T2 and T3) and one as control group (T0), Group T1 were supplemented with poly-herbal supplementation for seven day post partum, group T2 with poly-herbal supplementation for seven day post partum + 200 ml butyric acid supplementation for 30 day prepartum and 30 day postpartum and group T3 with 200 ml butyric acid supplementation for 30 day prepartum and 30 day postpartum. Data of Animals were analyzed for the sign of metritis, endometritis and anestrus. The study concealed that there was no incidence of metritis in supplemented (T1,T2 and T3)groups and was 11.11% in control groups. The incidence of endometritis waa 11.11 percent in both T1 and T3 group, it's lesser than C group was 22.2% percent. The anoestrus condition of murrah buffaloes in all the supplemented group (T1, T2 and T3 groups) was 11.11 percent which is lower than the control groups (22.22%). It could be concluded that the supplementation of poly-herbal mixture and butyric acid reduce the incidence of reproductive disorder and improve the reproductive performance of Murrah buffaloe.