author(s)
Guguloth Ramesh, D Madhuri, M Lakshman and A Gopal Reddy

abstract
This study was carried out to study histopathological changes in bone marrow (femur bone) induced by lead and cadmium alone and in combination on rats. Forty eight male albino Wistar rats were divided into 4 groups 12 rats in each group; group 1(control) was given deionized water, group 2 (lead group) was given water with lead acetate @30mg/kg b.wt, group 3 (cadmium group) was given water with cadmium chloride @15mg/kg b.wt, group 4 (combined group) was given water with both lead acetate@ 30mg/kg b.wt and cadmium chloride @15mg/kg b.wt for 28 days. Histopathological changes in bone marrow were recorded at 14^th day and 28^th day. Results showed group 2, 3 rats showed a progressive increase in adipocytes in bone marrow from 14^th to 28^th day and cellular portion of bone marrow was reduced. In group 4 most of the bone marrow was replaced by adipose tissue and cellular portion was reduced on 14^th and 28^th day of experimental period.